Endocrine Abstracts

Journal of Endocrinology 2013 219 51–58. DOI: 10.1530/JOE-13-0167...

Aim: Patients with type 2 diabetes (T2DM) have increased risk of cardiovascular disease (CVD) including stroke. The risk of CVD is traditionally assessed using office blood pressure (BP) and lipid profile. Increased arterial stiffness predicts cardiovascular events in the general population. We investigated if arterial stiffness was associated with cerebrovascular disease in patients with T2DM and sex- and age-matched controls indepentl y of classical risk factors.<p class...

Recent studies in various species have pointed out that Neurokinin B (NKB), encoded by Tac2 in rodents, and its receptor, NK3R, are important regulators of reproduction. NKB is co-expressed in Kiss1 neurons of the arcuate nucleus (ARC) and stimulates, via auto-regulatory loops, kisspeptin output onto GnRH neurons, therefore stimulating gonadotropin secretion. However, important aspects of the roles of NKB as regulators of the gonadotropic axis remain unknown. We report here th...

Introduction: Type 2 diabetes is associated with accelerated atherosclerosis, which causes macro-vascular complications such as cerebral infarctions, myocardial infarctions, and peripheral vascular disease. We aimed to investigate whether there are differences in the morphology of atherosclerosis in the carotid arteries assessed by MRI in newly diagnosed type 2 diabetic patients compared to non-diabetic control subjects.Methods: Hundred type 2 diabetic p...